Drostanolon

Drostanolon, oder Dromostanolon, ist ein anabolisch -undrogenes Steroid (AAS) der Dihydrotestosteron -Gruppe (DHT), die nie vermarktet wurde. [1] [2] [3] Ein Androgenester -Prodrug aus Drostanolon, Drostanolon Propionat, wurde früher bei der Behandlung von Brustkrebs bei Frauen unter Markennamen wie Drolban, Masteril und Masteron verwendet. [1] [2] [3] [4] Dies wurde auch nicht medizinisch für physikalische oder leistungssteigernde Zwecke verwendet. [3]

(2R,5S,8R,9S,10S,13S,14S,17S) -17-hydroxy-2,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-Tetreadecahydrocyclopenta [a] Phenanthren-3-One

C [c @@ h] 1c [c@] 2 ([c @@ h] (cc [c @@ h] 3 [c @@ h] 2cc [c@] 4 ([c@h] 3cc [C) @@ h] 4o) c) cc1 = o) c
Schlüssel: ikxildnpczpprv-rfmgovqksa-n n n

Inhalt

• 1 Pharmakologie
  • 1.1 Pharmakodynamik
  • 4.1 Generische Namen
  • 4.2 Rechtsstatus

  Pharmacodynamics Edit

  Wie andere AAs ist Drostanolon ein Agonist des Androgenrezeptors (AR). [3] Es ist kein Substrat für die 5α-Reduktase und ein schlecht. [3] Als DHT. [3] Während keine Daten zur progestogenen Aktivität von Drostanolon verfügbar sind, wird angenommen, dass es eine niedrige oder keine solche Aktivität hat wie bei anderen DHT -Derivaten. [3] Da das Medikament nicht 17α-alkyliert ist, ist nicht bekannt, dass es Hepatotoxizität verursacht. [3]

  Drostanolon, auch bekannt als 2α-methyl-5α-Dihydrotestosteron (2α-methyl-dht) oder als 2α-methyl-5α-Androstan-17β-ol-3-One, ist ein synthetisches Androstan-Steroid und ein Ableitung von DHT. [1] [2] [3] Es ist spezifisch DHT mit einer Methylgruppe an der C2α -Position. [1] [2] [3]

  Drostanolon und sein Ester Drostanolon Propionat wurden erstmals 1959 beschrieben. [3] [5] Drostanolon -Propionat wurde erstmals 1961 für den medizinischen Gebrauch eingeführt. [6]

  Generische Namen bearbeiten

  Drostanolon ist der generische Name des Arzneimittels und dessen Gasthaus, Verbot und DCF . [1] [2] Es wurde auch als bezeichnet Dromostanolon. [1] [2]

  Rechtsstatusbearbeitung

  Sie Konnen Anabolika im Besten -Geschaft Kaufen – steroids safe

  Bolazin ist bei React 2 Gl. mit Hydrazin, um Dimer zu geben

  Behandlung von DHT (Androstan-17β-ol-3-Eins, Stanolon) [521-18-6] (1) mit Methylformiat und dem starken Natriummethoxid ergeben [4033-95-8] (2). Die neu hinzugefügte Formylfunktion im Produkt wird in der ENOL -Form gezeigt. Die katalytische Hydrierung reduziert diese Funktion zu einer Methylgruppe (3). Die Zugabe von Wasserstoff von der unteren Oberfläche des Moleküls führt zur Bildung von β-Methylisomer, bei dem die Methylgruppe die höherenergetische axiale Position einnimmt. Eine starke baseninduzierte Äquilibrierung der Methylgruppe führt zur Bildung des sterisch bevorzugten äquatorialen α-Methyl-Isomers, das Dromostanolon bietet (4).

  1. ^ abcdef Elks J (14. November 2014). Das Wörterbuch der Arzneimittel: Chemische Daten: Chemische Daten, Strukturen und Bibliografien. Springer. pp. 652–. ISBN978-1-4757-2085-3 .
  2. ^ abcdef
  3. Index Nominum 2000: Internationales Arzneimittelverzeichnis. Taylor & Francis. Januar 2000. pp. 377–. ISBN978-3-88763-075-1 .
  4. ^ abcdefghichjk
  5. Llewellyn W (2011). Anabolics. Molecular Nutrition LLC. pp. 517–. ISBN978-0-9828280-1-4 .
  6. ^
  7. Bennett MB, Helman P, Palmer P (November 1975). „Hormonelle Therapie von Brustkrebs unter besonderer Berücksichtigung der Masteril -Therapie“. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde. 49 (49): 2036–40. PMID1242823.
  8. ^
  9. Ringold HJ, Batres E, Halpern O, Necoechea E (1959). „Steroide. Lebenslauf.12-Methyl- und 2-Hydroxymethylen-Androstan-Derivate „. Zeitschrift der American Chemical Society. 81 (2): 427–432. doi: 10.1021/JA01511A040. ISSN0002-7863.
  10. ^
  11. William Andrew Publishing (22. Oktober 2013). Pharmazeutische Fertigung Encyclopedia, 3. Auflage. Elsevier. pp. 1402–. ISBN978-0-8155-1856-3 .
  12. ^
  13. Karch SB (21. Dezember 2006). Handbuch für Drogenmissbrauch, zweite Ausgabe. CRC Press. pp. 30–. ISBN978-1-4200-0346-8 .
  14. ^
  15. Ringold HJ, Batres E, Halpern O, Necoechea E (Januar 1959). „Steroide. Lebenslauf. 1 2-Methyl- und 2-Hydroxymethylen-Androstan-Derivate „. Zeitschrift der American Chemical Society. 81 (2): 427–432. doi: 10.1021/JA01511A040.
  16. ^ Volovelskii, l.N. et al., Zh. Obschch. Khim., 1966, 46, 1772.
  17. ^US 2908693, Ringold HJ, Rosenkranz G, ausgestellt 1959, zugewiesen an Syntex SA
  18. ^
  19. US 3118915, Ringold HJ, Rosenkranz G, ausgestellt 1964, zugewiesen an Roche Palo Alto LLC
  20. ^
  21. GB 1005896
  22. US 3249627, ausgestellt 1966, zugewiesen an Ormonoterapia Richter Spa

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